CREB Can Get You Depressed

NRPE accumulates and all-trans-ROL levels are tranDean Bok siently decreased due to the inability of all-trans-RAL Department of Neurobiology and Ophthalmology to gain access to the dehydrogenase. School of Medicine The reconstitution studies of Sun et al. (1999) utilized University of California, Los Angeles a large array of potential substrates and demonstrated Los Angeles, California 90095 that all-trans-RAL is the most likely substrate since it stimulates ABCR ATPase activity 3to 4-fold with a halfSelected Reading maximal effect at 10–15 mM. This stimulatory effect was Allikmets, R., Singh, N., Sun, H., Shroyer, N.F., Hutchinson, A., Chiobserved only when PE was present in the proteolipodambaram, A., Gerrard, B., Baird, L., Stauffer, D., Peiffer, A., et al. somes. This is also consistent with the notion that the (1997). Nat. Genet. 15, 236–246. NRPE complex is the form actually transported. Bok, D. (1993). J. Cell Sci. 17 (suppl.), 189–195. A second, interesting feature of the ABCR null mice Dowling, J. (1960). Nature 168, 114–118. is the observation that their RPE accumulates lipofuscin Eldred, G.E. (1995). Gerontology 41, 15–28. at a much faster rate than wild-type controls. Lipofuscin Eldred, G.E., and Lasky, M.R. (1993). Nature 361, 724–726. consists of material that cannot be degraded by lyso-